Wed like to understand how you use our websites in order to improve them. Oral drug delivery remains the preferred route for administration of various drugs 1. The following mechanisms are responsible for the breaking of tablets and bulk contents of capsules into small pieces. Mechanism of superdisintegrants free download as word doc. Mechanism of superdisintegrants porosity free 30day trial scribd. Superdisintegrants are utilizing the structural weakened for the breakup of tablet.
The basic approach in development of fdt is the use of superdisintegrants like cross linked carboxymethyl. As tableting becomes more advanced, formulators prefer direct compression blends. Due to swelling of the superdisintegrants, the wetted surface of the carrier increases, this promotes the wettability and dispersibility of the system, thus. Design of superdisintegrant and effervescent agentless. The aims of this study are 1 to compare the disintegration efficiency, and 2 to develop a discriminating test model for the 3 classes of superdisintegrants represented by acdisol, primojel, and polyplasdone xl10. A total of six formulations and control formulation cp 0without superdisintegrant were designed. Super disintegrants tablet pharmacy pharmaceutical. Influence of different superdisintegrants on losartan potassium orodispersible tablets. Mechanism of disintegrations by superdisintegrants there are five major mechanisms for tablet disintegration as follows.
Disintegrants and superdisintegrants excipients for. Should have rapid disintegration rate when tablet comes in contact with saliva in mouth. Bolhuis and coworkers 5 studied a series of experimental ssg having a relative degree of crosslinking dxl of 0. Superdisintegrants which were added to the drug formulations facilitated the breakup or disintegration of tablet content into smaller particles that dissolved more rapidly. With improved bioavailability vishwakarma, divya, patel, natvarlal, patel, kanu on. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1 10 % by weight relative to the total weight of the dosage unit.
The advantages of using superdisintegrants, sodium starch glycolate ssg, croscarmellose sodium ccs and crospovidone cp over traditional high molecular weight mw viscosity enhancing agents, guar gum gg, xanthan gum xg, pectin and high mw hpmc are examined for improving drug content uniformity without compromising dissolution of films containing nanoparticles of griseofulvin gf. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The majority of this research has been directed at the functionrelated properties of the superdisintegrants with special emphasis on correlating these properties to disintegrant efficiency and drug release. To study the influence of superdisintegrants on the performance of losartan potassium, a set of two formulations f1 and f2 were prepared using two superdisintegrants viz, sodium starch glycolate 5% and crospovidone 5% respectively. Effective superdisintegrants provide improved compressibility, compatibility and have no negative impact on the mechanical strength of formulations containing highdose drugs. Superdisintegrants, utility in dosage forms journal of. The objective of this study was to evaluate the functionality and performance of three types of commonly used commercial superdisintegrants, crosslinked croscarmellose sodium xlcmc, crospovidone, and sodium starch glycolate ssg, in the application of odts. Each dissolution experiment is run in tripilicate n3. Method of incorporation of superdisintegrants as shown in table 2.
Solid dosage forms are popular because of ease of administration, accurate dosage, selfmedication, pain evasion and most importantly the patient compliance 2 however, traditional tablets and capsules have emerged as inconvenient or unfeasible for some geriatric patients because of changes in. Analysis of patents pertaining to superdisintegrants used. Superdisintegrants generally are used at a low level in the solid dosage form, typically 110% by weight relative to the total weight of the dosage unit. Comparison of superdisintegrants in orally disintegrating. Journal of drug delivery and therapeutics superdisintegrants. Unlike other superdisintegrants which are either poorly compressible or noncompressible, crospovidone disintegrants are highly compressible materials as a result. All superdisintegrants except prosolve were used at 4% concentration and prosolve was used at 10% concentration. Pulla reddy college of pharmacy, mehidipatnam, hyderabad, 500 028, india, 2. Novel use of superdisintegrants as viscosity enhancing. Disintegrants play a major role in the disintegration and dissolution of mdt. Fast dissolving tablet of metoprolol tartrate using. Due to disintegrating particleparticle repulsive forces 5.
As the blends were free flowing angle of repose free solution this solution was kept aside for some time. In this mechanism, superdisintegrants swell when they come in contact with water e. Disintegrants and superdisintegrants are used in tablets and capsules to ensure the rapid break down into their primary particles, facilitating the dissolution or release of the active ingredients. Superdisintegrants improve disintegration efficiency and decrease use levels compared to traditional disintegrants. Superdisintegrants provide quick disintegration due to combined effect of swelling and water absorption by the formulation. It is effective when used intragranular andor extragranular in granular formulations. The behavior of superdisintegrants in various tablet formulations has been investigated by many researchers 26. A complete analysis of the patents granted on superdisintegrants was done using various criteria such as patenting trends over the years, country wise distribution and different classes of superdisintegrants. Results and discussion paracetamol fdts were formulated employing four superdisintegrants namely crospovidone, croscarmellose sodium. These solutions were slowly casted with a continuous flow on teflon plate of diameter 6 cm in order to avoid bubble formation.
Superdisintegrants for solid dispersion to produce rapidly disintegrating tenoxicam tablets via camphor sublimation adel m. Comparison of diclofenan mouth dissolving tablet with fenugreek and sodium. Disintegration by capillary action is always the first step. Fast dissolving tablet of metoprolol tartrate using superdisintegrants. Superdisintegrants shrivastava priyanka and sethi vandana department of pharmaceutics, lloyd college of pharmacy, greater noida, u. Design of orodispersible tablets of losartan potassium. The requirement placed on the tablet disintegrant should be clearly defined. Disintegrant definition of disintegrant by medical. Mechanism of superdisintegrants superdisintegrants provide quick disintegration. Scribd is the worlds largest social reading and publishing site.
Perhaps the most widely accepted general mechanism of action for tablet disintegration is swelling. Qato the authors examined the effects of three superdisintegrants kollidon cl,acdisol,and primojel on the dissolution and absorption of tenoxicam from soliddispersion formulations. The present work was aimed at formulation development, evaluation and comparative study of the effects of superdisintegrants in cefixime 50 mg oral disintegrating tablets. Comparison of diclofenan mouth dissolving tablet with fenugreek and sodium starch glycolate as superdisintegrants ray, chanda on. Superdisintegrants in the development of orally disintegrating tablets. Pdf superdisintegrants in the development of orally disintegrating. Examples of superdisintegrants are crosscarmelose, crospovidone, and sodium starch glycolate, which are a crosslinked cellulose, crosslinked polymer, and a crosslinked starch, respectively. Thus, a new disintegrant class called superdisintegrants has emerged in the market. Superdisintegrants market analysis by product, by dosage. Pdf effect of superdisintegrants on dissolution of. By analysing patents on superdisintegrants, research gaps can be identified and the research work to be taken up can be focused.
Thus the superdisintegrants are incorporated within the granules. On contact with water the superdisintegrants swell, hydrate, change volume or form and produce a disruptive change in the tablet. Extragranular or prior to compression in this process, the superdisintegrants are mixed with prepared granules before compression. Other superdisintegrants have a lower crosslink density and, as a result, form gels when fully hydrated, particularly at the higher use levels in odt formulations.
Superdisintegrants that tend to swell show slight retardation of the disintegration property due to formation of viscous barrier. Directly compressible mannitol pearlitol sd 200 was used as a diluent to enhance mouth feel. Since superdisintegrant is used as an excipient in the tablet formulation, it has to meet certain criteria other than its swelling properties. Pdf the desire of improved palatability in orally administered products has prompted the development of numerous formulations with. From table 2 and 3 it is clear that nature and method of incorporation of superdisintegrants has a great effect on the dt of carbamazipine tablets. Download fulltext pdf effect of superdisintegrants on dissolution of cationic drugs article pdf available in dissolution technologies 152 may 2008 with 973 reads. The most widely accepted general mechanism of action for tablet disintegration is swelling. The objective of the present article is to highlight the various kinds of. Superdisintegrants act by different mechanism of action. Pdf superdisintegrants in the development of orally. The superdisintegrants used for the present study were sodium starch glycolate and crosscarmellose sodium.
Superdisintegrants are used to improve the efficacy of solid dosage forms. The formed film was taken out after 24 hrs from hot air oven and checked. International journal of biopharmaceutics superdisintegrants. Roquette has developed a versatile range of standard disintegration excipients. The present study comprises the various kinds of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patients compliance. Various superdisintegrant along with their mechanism of. The various sources of superdisintegrants and their modification to improve disintegration.
462 248 920 916 35 204 898 984 710 403 116 174 91 716 1507 232 268 1148 1078 598 239 405 601 501 734 95 465 1182 1512 1123 472 502 519 317 1037 2 869 845 974